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Guidelines for documenting analytic assumptions and sensitivity analyses to support reproducible and transparent research.
Transparent, reproducible research depends on clear documentation of analytic choices, explicit assumptions, and systematic sensitivity analyses that reveal how methods shape conclusions and guide future investigations.
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Published by Henry Griffin
July 18, 2025 - 3 min Read
When researchers document analytic workflows, they establish a roadmap for readers to follow from data to inference. The clearest reports describe the entire modeling journey, including the motivation for choosing a particular method, the assumptions embedded in that choice, and the ways in which data support or contradict those premises. This foundation matters because analytic decisions often influence estimates, uncertainty, and interpretation. By narrating the rationale behind each step and tying it to measurable criteria, researchers create a reproducible trail. The narrative should emphasize what is known, what remains uncertain, and how alternative specifications could alter conclusions. A transparent start reduces ambiguity and invites constructive critique.
A robust practice is to articulate analytic assumptions in plain language before presenting results. Specify functional forms, prior distributions, data transformations, and any imputation strategies. Clarify the domain of applicability, including sample limitations and potential biases that may arise from nonresponse or measurement error. Transparency also means labeling where assumptions are informal or conjectural, and indicating how they would be tested. When feasible, pre-registering analytic plans or posting a registered report can further strengthen credibility. Ultimately, the goal is to replace vague confidence with concrete, testable statements that readers can evaluate and, if needed, replicate with their own data.
Sensitivity analyses should be prioritized and clearly documented for examination.
Sensitivity analyses serve as a critical complement to point estimates, revealing how conclusions shift when inputs change. A well-structured sensitivity study explores plausible variations in key parameters, model specifications, and data processing choices. It helps distinguish robust findings from artifacts produced by particular decisions. To maximize usefulness, report the range of results, the conditions that trigger notable changes, and the probability or impact of those changes in practical terms. Readers should be able to assess whether uncertainty is dominated by data limitations, structural model choices, or external factors beyond the dataset. Documenting this landscape makes conclusions more credible and less brittle.
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When designing sensitivity analyses, prioritize factors that experts deem influential for the question at hand. Begin with baseline results and then methodically alter a handful of assumptions, keeping all other components fixed. This approach isolates the effect of each change and helps prevent overinterpretation of coincidental variation. Include both positive and negative checks, such as using alternative measurement scales, different inclusion criteria, and varying treatment of missing values. Present the outcomes transparently, with clear tables or figures that illustrate how the inferences evolve. The emphasis should be on what remains stable and what warrants caution.
Transparency around methods, data, and replication is foundational to credibility.
Reporting assumptions explicitly also involves describing the data-generating process as far as is known. If the model presumes independence, normality, or a particular distribution, state the justification and show how deviations would affect results. When those conditions are unlikely or only approximately true, provide justification and include robustness checks that simulate more realistic departures. Alongside these checks, disclose any data cleaning decisions that could influence conclusions, such as outlier handling or transformation choices. The objective is not to pretend data are perfect, but to reveal how the analysis would behave under reasonable alternative perspectives.
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Another essential element is the documentation of software and computational details. Specify programming languages, library versions, random seeds, hardware environments, and any parallelization schemes used. Include access to code where possible, with reproducible scripts and environment files. If full replication is not feasible due to proprietary constraints, offer a minimal, sharable subset that demonstrates core steps. The intention is to enable others to reproduce the logic and check the results under their own systems. Detailed software notes reduce friction and build confidence in the reported findings.
Documenting data limitations and mitigation strategies strengthens interpretation.
Protocols for documenting analytic assumptions should also address model selection criteria. Explain why a particular model is favored over alternatives, referencing information criteria, cross-validation performance, or theoretical justification. Describe how competing models were evaluated and why they were ultimately rejected or retained. This clarity prevents readers from assuming vanity choices or undisclosed preferences. It also invites independent testers to probe the decision rules and consider whether different contexts might warrant another approach. In short, explicit model selection logic anchors interpretation and fosters trust in the research process.
Beyond model selection, researchers should report how data limitations influence conclusions. For example, discuss the consequences of limited sample sizes, measurement error, or nonresponse bias. Show how these limitations were mitigated, whether through weighting, imputation, or sensitivity to missingness mechanisms. When possible, quantify the potential bias introduced by such constraints and compare it to the observed effects. A candid treatment of limitations helps readers gauge scope and relevance, reducing overgeneralization and guiding future studies toward more complete evidence.
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Clear labeling of exploratory work and confirmatory tests supports integrity.
A comprehensive reproducibility plan also includes a clear data stewardship narrative. Specify whether data are publicly accessible, restricted, or controlled, and outline the permissions required to reuse them. Provide metadata that explains variable definitions, coding schemes, and timing. When data cannot be shared, offer synthetic datasets or detailed specimen code that demonstrates analytic steps without exposing sensitive information. The aim is to preserve ethical standards while enabling scrutiny and replication in spirit if not in exact form. This balance often requires thoughtful compromises and explicit justification for any withholding of data.
Another practice is to distinguish exploratory from confirmatory analyses. Label exploratory analyses as hypothesis-generating and separate them from preplanned tests that address predefined questions. Guard against cherry-picking results by pre-specifying which outcomes are primary and how multiple comparisons will be handled. Transparent reporting of all tested specifications prevents selective emphasis and helps readers assess the strength of conclusions. When surprising findings occur, explain how they emerged, what checks were performed, and whether they should be pursued with new data or alternative designs.
Finally, cultivate a culture of ongoing revision and peer engagement. Encourage colleagues to critique assumptions, attempt replications, and propose alternative analyses. Early, open discussion about analytic choices can surface hidden biases and reveal gaps in documentation. Treat reproducibility as a collaborative practice rather than a bureaucratic hurdle. By welcoming constructive critique and updating analyses as new information becomes available, researchers extend the longevity and relevance of their work. The discipline benefits when transparency is not a one-time requirement but a sustained habit embedded in project governance.
In practice, reproducibility becomes a measure of discipline—an everyday standard of care rather than an afterthought. Integrate detailed notes into data-management plans, supplementaries, and public repositories so that others can trace the lineage of results from raw data to final conclusions. Use consistent naming conventions, version control, and timestamped updates to reflect progress and changes. By embedding explicit assumptions, rigorous sensitivity checks, and accessible code within the research lifecycle, the scientific community builds a robust foundation for cumulative knowledge, where new studies confidently build on the transparent work of others.
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