Pharmacology & drugs
How to implement multi-disciplinary rounds focused on medication optimization to reduce adverse drug events in hospitals.
A practical guide outlines structured, collaborative rounds that align clinicians, pharmacists, and nurses to review medications, reduce errors, and improve patient safety outcomes across hospital settings.
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Published by Martin Alexander
July 16, 2025 - 3 min Read
Multidisciplinary rounds focused on medication optimization require deliberate design, clear goals, and shared language among physicians, pharmacists, nurses, and data analysts. Establishing an arena for open dialogue, these rounds center on patient-specific drug therapy, including indications, doses, routes, and potential interactions. Teams must define success metrics such as reduced adverse drug events, improved adherence to evidence-based protocols, and timely de-prescribing where appropriate. Accessibility of patient histories, allergy lists, and current medication reconciliations supports informed decision-making. Regular schedules, protected time, and leadership facilitation help sustain momentum and encourage consistent participation from diverse disciplines across the hospital system.
Before launching rounds, assemble a core governance group that includes clinical leaders from medicine, pharmacy, nursing, and informatics. This group designs the run-of-show, including daily responsibilities, patient selection criteria, and escalation pathways for urgent safety issues. A standardized checklist guides each session, prompting review of high-alert medications, duplications, dosing errors, renal dosing adjustments, and potential drug–drug interactions. Integrating real-time decision support tools with electronic health records enhances the team's ability to verify recommendations. Training sessions align team members on terminology, risk assessment frameworks, and the appropriate use of de-prescribing when therapeutic goals have shifted.
Structured discussions that promote learning, not blame.
The first key step is selecting patients who are most at risk for adverse drug events. Criteria include polypharmacy, recent hospital transitions, kidney or liver impairment, and recent changes in therapy. By prioritizing complex cases, the team can demonstrate tangible improvements quickly, which reinforces engagement. During each session, a pharmacist leads medication reconciliation, while physicians evaluate clinical necessity. Nurses contribute insights about tolerance, symptoms, and adherence barriers. Data analysts provide up-to-date event trends, enabling the group to identify recurring patterns. The round concludes with action plans, responsible team members, and follow-up dates to measure impact.
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Beyond case-by-case reviews, rounds should cultivate a culture of proactive safety. This involves challenging assumptions, validating therapeutic goals with patients and families, and documenting rationales for changes. The team must distinguish between necessary dose adjustments and unnecessary persistent therapies, particularly with opioids, antipsychotics, and high-risk anticoagulants. Regular audit feedback helps clinicians learn from near misses and actual events alike. Additionally, educational updates about pharmacology advances, dosing benchmarks, and guideline changes keep practice aligned with current best evidence. Comfortable hierarchy levels during rounds encourage junior staff to contribute observations without fear of criticism.
Operationalizing rounds with clear roles and responsibilities.
Engaging patients and caregivers in medication optimization is essential for success. Clear explanations about why changes are proposed, potential benefits, and possible risks build trust and consent. Shared decision-making supports adherence and empowers patients to participate in their own safety. The team should provide written summaries of recommendations, including expected outcomes and follow-up plans. Transparent communication standards reduce confusion during transitions of care, such as discharge planning or transfer between units. By documenting patient preferences and goals, clinicians can tailor therapy to individual needs while maintaining safety as a central priority.
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When implementing recommendations, a standardized execution process ensures consistency across shifts and units. The pharmacist coordinates dispensing updates, dosage recalibrations, and formulary alternatives, while the physician confirms indications and monitors for clinical improvement. Nursing staff monitor administration times, infusion rates, and any patient-reported adverse effects. IT support ensures that alerts are meaningful and do not contribute to alarm fatigue. A structured handoff protocol transfers responsibility smoothly between providers. Regularly reviewing outcomes data helps identify gaps in implementation and fosters continuous quality improvement.
Embedding rounds in daily practice through culture and metrics.
Effective rounds depend on robust data governance. The team relies on accurate medication lists, active problem lists, and timely reconciliation across admissions, transfers, and discharges. A dashboard highlights high-risk patients, recent adverse events, and deviations from recommended guidelines. Pharmacists play a central role in flagging dose inconsistencies, while physicians assess clinical necessity and alternatives. Nurses document patient experiences, adherence challenges, and practical constraints in administration. Informatics specialists tune decision-support alerts to minimize false positives, ensuring attention remains focused on clinically meaningful risks. The governance framework should remain flexible to accommodate evolving evidence and institutional priorities.
Leadership support and protected time are crucial for sustaining rounds. Administrators should allocate dedicated space, remove competing duties, and recognize staff contributions. Scheduling should align with unit workflows to minimize disruption while maximizing participation. Regular debriefings after rounds help refine processes, celebrate successes, and address bottlenecks. Institutions may implement standardized metrics such as reduced incidence of medication errors, shorter hospital stays, and improved patient satisfaction tied to safer medication practices. Over time, this approach can evolve into a core component of the hospital’s safety culture and accreditation readiness.
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Sustaining momentum through continuous learning and collaboration.
An effective measurement framework translates process changes into meaningful outcomes. Primary metrics include the rate of adverse drug events, time to resolution of identified drug-related problems, and adherence to evidence-based dosing guidelines. Secondary measures assess patient understanding, discharge medication accuracy, and readmission rates related to medication issues. Continuous data collection enables trend analysis and benchmarking against peer institutions. Transparent reporting to leadership drives accountability and informs strategic investments in pharmacy personnel, technology, and staff education. In parallel, patient safety rounds should integrate with other quality initiatives to create a cohesive safety net across the hospital.
Interprofessional education strengthens rounds by connecting theory to practice. Joint training sessions foster mutual respect and clarify the expertise each discipline brings to medication optimization. Case simulations and reflective debriefings cultivate shared mental models, enhancing communication during real events. Mentorship programs pair experienced clinicians with trainees to transfer tacit knowledge about dosing, monitoring, and problem-solving. Over time, these educational efforts normalize collaborative decision-making, reduce hierarchical friction, and create lasting improvements in patient safety culture across wards and departments.
Patient-centered communication remains foundational to successful rounds. Clinicians should practice empathetic listening, validate concerns about side effects, and discuss realistic expectations for therapy. Well-framed conversations about risks and benefits support informed choices and adherence. Documentation should reflect these conversations, ensuring future care teams understand decisions and rationales. Regular feedback from patients and families informs process refinements and highlights areas for improvement. By combining patient voices with data-driven insights, rounds become more credible and harder to abandon as a safety strategy.
Finally, scale and spread successful models responsibly. Start with pilot units, demonstrate measurable gains, and document transferable practices. When expanding, adapt workflows to different specialties, patient populations, and resource levels, rather than enforcing a one-size-fits-all approach. Maintain disciplined governance, update protocols with new evidence, and preserve the core aim of minimizing harm from medications. By treating medication optimization rounds as an integral health-systems endeavor, hospitals can achieve durable reductions in adverse drug events and improve overall patient outcomes.
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