Pharmacology & drugs
Strategies for reducing inappropriate antipsychotic use in long-term care by implementing behavioral and environmental interventions.
A practical, evidence-based guide for reducing inappropriate antipsychotic use in long-term care settings through integrated behavioral and environmental strategies that prioritize person-centered care, staff support, and nonpharmacological approaches to agitation and behavioral challenges.
X Linkedin Facebook Reddit Email Bluesky
Published by Peter Collins
July 16, 2025 - 3 min Read
In many long-term care facilities, antipsychotics are used to manage behaviors associated with dementia or mental illness, sometimes without a thorough assessment or ongoing review. This practice raises concerns about safety, effectiveness, and the risk of adverse effects. When residents receive these medications inappropriately, the consequences can include falls, cognitive decline, metabolic complications, and reduced quality of life. A shift toward behavioral and environmental strategies requires commitment from leadership, clear policy guidelines, and a culture that values nonpharmacological care as a first option. By focusing on assessment, alternatives, and monitoring, facilities can begin to reduce reliance on antipsychotics responsibly.
The first step is a comprehensive review of current pharmacologic regimens and documentation. Clinicians should verify indications, confirm that nonpharmacologic strategies have been attempted, and establish a plan for deprescribing where feasible. Regular multidisciplinary rounds are essential, including physicians, nurses, pharmacists, therapists, and family members. These teams can identify symptom triggers, track response to interventions, and determine when a medication can be tapered or discontinued. Documentation should reflect the resident’s goals, preferences, and informed consent. Transparent communication with families helps align expectations and fosters trust, which is crucial when changing entrenched treatment patterns.
Build a sustained, collaborative structure for ongoing deprescribing and care improvement.
Behaviorally informed care in long-term settings involves structured routines, predictable environments, and consistent responses to triggers. Staff can learn to interpret agitation as communication, not defiance, and respond with calm, nonintrusive techniques. Environmental adjustments such as improved lighting, reduced noise, and meaningful activities can decrease agitation. Person-centered activities tailored to each resident’s history and preferences enhance engagement and reduce distress. Training programs should emphasize de-escalation skills, boundary setting, and the use of nonpharmacological comfort measures. By aligning environmental design with individualized care plans, the facility supports safer behavior management while minimizing medication reliance.
ADVERTISEMENT
ADVERTISEMENT
Conversely, environmental interventions also require ongoing evaluation. Regular assessment of scent, noise level, and crowding can reveal how stimuli contribute to challenging behaviors. Scheduling changes—like quiet periods after meals, predictable mealtimes, and structured social opportunities—provide stability. Accessibility to favorite objects, reminiscence corners, and familiar routines fosters a sense of safety. Collaboration with occupational and physical therapists helps adapt activities to functional abilities. When staff see tangible improvements through observations and resident feedback, the rationale for avoiding unnecessary antipsychotics strengthens, and families notice a more humane approach to care.
Integrate regular reviews and pharmacist support with resident-focused deprescribing.
Staff education is a foundational pillar for reducing inappropriate antipsychotic use. Ongoing training should cover pharmacology basics, nonpharmacologic alternatives, and the ethical dimensions of sedation. Educational modules can include case studies, crisis de-escalation drills, and peer coaching. Empowering frontline caregivers to implement behavioral strategies increases confidence and reduces perceived dependence on medications. Importantly, education must be reinforced by supportive supervision, feedback loops, and opportunities for reflection after challenging shifts. When staff feel equipped and supported, they are more willing to try nondrug approaches, document outcomes, and participate in deprescribing plans alongside clinicians.
ADVERTISEMENT
ADVERTISEMENT
Pharmacists play a pivotal role in stewardship within long-term care. They can conduct medication reviews, flag potential drug interactions, and suggest tapering schedules aligned with residents’ goals. Pharmacists collaborate with prescribers to identify alternative therapies for agitation, anxiety, or psychosis, including nonpharmacologic interventions and nutritional optimization. They can also help monitor withdrawal symptoms, ensuring patient safety during dose reductions. Regular audits of antipsychotic use, with feedback to the care team, reinforce best practices. By embedding pharmaceutical expertise into daily rounds, facilities strengthen accountability and create measurable improvements in medication appropriateness.
Implement targeted, proactive strategies to minimize antipsychotic exposure.
Family engagement is essential to the deprescribing journey. Families bring context about personal history, triggers, and meaningful routines that may reduce distress when honored in care plans. Transparent conversations about risks, benefits, and the goals of care help align expectations. Families should be invited to participate in care conferences, contribute to nonpharmacologic strategies, and celebrate successes when agitation declines without medications. Providing education to families about potential withdrawal effects and monitoring responsibilities strengthens partnership. When families witness concrete adjustments—more participation in activities, fewer episodes of aggression, and safer sleep patterns—support for nonpharmacologic care grows.
Nonpharmacologic interventions for behavioral symptoms include individualized activity programs, music and art therapies, reminiscence, and pet-assisted therapies where appropriate. These approaches can reduce agitation and aggression while enriching emotional well-being. Staff should document residents’ responses to different activities, noting which strategies yield the most benefit with the least risk. Sensory integration techniques, such as weighted blankets or tactile stimulation, may be helpful for some residents when used cautiously. Environmental enrichment, social engagement, and meaningful routines together create a supportive ecosystem that diminishes the perceived need for antipsychotics.
ADVERTISEMENT
ADVERTISEMENT
Sustain momentum through ongoing evaluation, education, and leadership.
Behavioral management plans should begin with a thorough assessment of reversible causes. Pain, urinary retention, infection, constipation, or sensory deficits can masquerade as behavioral disturbances. Treating these underlying issues often reduces agitation without drugs. Sleep disturbances, delirium risk, and inadequate hydration must also be addressed. A systematic approach ensures that medications are not chosen as first-line solutions. When nonpharmacologic strategies fail to control severe symptoms, clinicians can consider cautious, monitored pharmacologic steps, prioritizing the lowest effective dose for the shortest duration while pursuing deprescribing as promptly as possible.
Data-driven monitoring supports accountability and progress. Care teams should track rates of antipsychotic prescribing, dose changes, adverse events, and time to deprescribing milestones. Analytics help identify facilities with sustainable improvements and those needing targeted support. Sharing success stories and lessons learned fosters a learning culture that values continuous improvement. Regular performance dashboards, coupled with peer mentoring, keep deprescribing goals visible and actionable. Residents and families benefit from transparent reporting that demonstrates commitment to safe, person-centered care and careful medication use.
Leadership commitment is critical to long-term success. Administrators must allocate resources for staffing, training, and environmental upgrades while maintaining a clear policy that prioritizes nonpharmacologic care. Leadership should champion regular interdisciplinary rounds, deprescribing protocols, and family engagement initiatives. Clear lines of accountability help ensure adherence to guidelines, smooth implementation of changes, and timely addressing of concerns. A culture that celebrates small wins—fewer antipsychotic days, improved resident comfort, and enhanced well-being—motivates teams to persevere. When leaders model values centered on dignity and safety, the entire organization benefits through safer, more compassionate care.
Finally, ongoing research and quality improvement enrich practice. Facilities can participate in learning collaboratives, contribute to registries, and adopt innovative behavioral interventions. Continuous improvement cycles—plan, do, study, act—allow teams to test new strategies, measure outcomes, and refine approaches. Sharing results with staff, residents, and families reinforces trust and engagement. As evidence accumulates around alternatives to antipsychotics, long-term care can evolve toward care models that respect autonomy, protect health, and reduce unnecessary pharmacologic exposure. The path is incremental but meaningful, delivering lasting benefits for residents and care teams alike.
Related Articles
Pharmacology & drugs
A clear, parent-centered guide offering structured routines, reliable measurement tools, safe storage habits, and careful communication with healthcare providers to support accurate pediatric dosing and safer medication use.
July 27, 2025
Pharmacology & drugs
Establishing reliable, scalable workflows for abnormal lab results tied to medication therapy improves safety, reduces delays, and supports personalized care by ensuring timely review, verification, and communication among clinicians, patients, and laboratories.
August 04, 2025
Pharmacology & drugs
A comprehensive, patient-centered overview of strategies to prevent and treat constipation linked to opioid use, emphasizing practical steps, safety, and collaborative care to maintain daily functioning and comfort.
August 03, 2025
Pharmacology & drugs
This evergreen guide outlines a practical, evidence-based approach to crafting antibiotic prophylaxis protocols for surgery, balancing effectiveness with safety, stewardship principles, and patient-centered considerations in diverse clinical settings.
July 18, 2025
Pharmacology & drugs
Clinicians guide patients through the dangers of combining sedatives, outlining clear harm reduction steps and practical strategies to prevent overdose while preserving safety and autonomy.
August 07, 2025
Pharmacology & drugs
Clinicians face complex decisions when medications trigger mood changes or psychotic symptoms; this guide outlines assessment, monitoring, collaboration, and mitigation strategies to protect patient safety and optimize care.
July 16, 2025
Pharmacology & drugs
This evergreen guide explores how stigma around psychiatric medications shapes patient choices, and offers evidence-based approaches to foster trust, reduce fear, and boost sustained engagement in comprehensive mental health care.
July 26, 2025
Pharmacology & drugs
This evergreen guide outlines practical, evidence-based approaches to enhance outpatient oncology medication safety by standardizing prescribing, employing cross-disciplinary reviews, leveraging digital tools, and fostering a culture of continuous safety improvement across the care continuum.
August 07, 2025
Pharmacology & drugs
A practical guide for clinicians to coach patients through safe medication practices when acute illness disrupts routine dosing, ensuring efficacy, reducing risk, and supporting informed decision making in real world settings.
July 17, 2025
Pharmacology & drugs
This article outlines proven strategies for integrating clinical pharmacists as leaders of discharge medication reconciliation, detailing collaboration, workflow design, evidence-based checks, and patient-centered communication that minimize errors and ensure continuity of care.
August 03, 2025
Pharmacology & drugs
Clinicians must assess the enduring benefits and risks of long-term benzodiazepine use, weighing dependence, cognitive effects, and tolerance, while exploring safer alternatives and structured taper plans to minimize withdrawal and relapse.
July 21, 2025
Pharmacology & drugs
Pharmacist-led medication therapy management reshapes outpatient care by optimizing dosing, reducing adverse events, and strengthening collaborative practices between clinicians, patients, and caregivers to sustain safer, more effective treatments over time.
August 06, 2025